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Updated: Jan 27, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
Published on: October 31, 2013
Making light work of fine-tuning channelrhodopsins
Andrew J Moorhouse1, John M Power
1From the School of Medical Sciences, UNSW Sydney, New South Wales, 2052, Australia a.moorhouse@unsw.edu.au.
Abstract:
The development of genetically engineered proteins that can control cell excitability with light have revolutionized our understanding of the nervous system. The most widely used of these optogenetic tools is the light-gated ion channel, channelrhodopsin 2 (ChR2). A new study by Cho et al. describes the development of ChR2 variants with improved photocurrents and more selective ion permeability using an automated multifaceted fluorescence-based screening. This methodological framework holds promise not only in refining features of ChR2, but also for other proteins in which fluorescence phenotyping is possible.
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08:39Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
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07:04Long-range Channelrhodopsin-assisted Circuit Mapping of Inferior Colliculus Neurons with Blue and Red-shifted Channelrhodopsins
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