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A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
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Endovascular therapy for acute severe pulmonary embolism
Qasim A Javed1, Akhilesh K Sista2
1NYU Langone Health, New York, USA. qasim.javed@nyumc.org.
The International Journal of Cardiovascular Imaging
|March 17, 2019
Summary
Acute pulmonary embolism (PE) is a significant cause of death. This review focuses on current therapies for managing massive and submassive PE, which have high mortality rates.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Critical Care Medicine
Background:
- Acute pulmonary embolism (PE) is a leading cause of mortality in the United States, responsible for 100,000-180,000 deaths annually.
- Current risk stratification categorizes PE into massive, submassive, and low-risk based on hemodynamic stability, right ventricular dysfunction, and myocardial necrosis.
- These categories are associated with distinct mortality rates: massive PE (25-65%), submassive PE (3%), and low-risk PE (<1%).
Purpose of the Study:
- To review and summarize the therapeutic options currently available for the management of acute massive and submassive pulmonary embolism.
- To provide an overview of the current treatment landscape for high-risk PE patients.
Main Methods:
- Literature review of existing studies and clinical guidelines.
- Synthesis of information on pharmacological and interventional therapies for acute PE.
- Focus on treatments applicable to massive and submassive PE classifications.
Main Results:
- The review details various therapeutic strategies for acute massive and submassive PE.
- Specific treatments aim to improve hemodynamic stability and reduce mortality in high-risk patients.
- The efficacy and application of different management approaches are discussed.
Conclusions:
- Effective management of massive and submassive PE is crucial due to their significant associated mortality.
- Current therapeutic strategies offer options for improving outcomes in these critically ill patients.
- Further research may refine treatment protocols for acute pulmonary embolism.
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