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Related Concept Videos

What are Lipids?01:38

What are Lipids?

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Overview
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What are Lipids?01:31

What are Lipids?

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Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
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Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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Structure of Lipids03:38

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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Lipid Catabolism01:25

Lipid Catabolism

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Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
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Lipids as Anchors01:32

Lipids as Anchors

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In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
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Determination of Total Lipid and Lipid Classes in Marine Samples
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Latest Updates on Lipid Management.

Emmanuel Eroume-A Egom1,2, Rebabonye B Pharithi3, Soressa Hesse3

  • 1Department of Clinical Medicine, Education Division, School of Medicine, Trinity College Dublin, Dublin, Ireland. egom@ectrs.ca.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|March 17, 2019
PubMed
Summary
This summary is machine-generated.

Atherosclerotic cardiovascular disease (ASCVD) remains a global health threat. This review highlights current lipid management strategies and cholesterol-lowering agents to improve ASCVD prevention and treatment outcomes.

Keywords:
ASCVDAtherosclerotic cardiovascular diseaseCholesterolLipid managementTriglycerides

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Area of Science:

  • Cardiology
  • Vascular Medicine
  • Pharmacology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is the primary cause of mortality globally.
  • Despite proven benefits in primary and secondary prevention, cholesterol management is often suboptimal, with many patients failing to reach target levels.
  • Under-treatment of high cholesterol contributes significantly to the ASCVD burden.

Purpose of the Study:

  • To provide an updated review of lipid management strategies for ASCVD.
  • To emphasize the clinical applications of various cholesterol-lowering drug classes.
  • To inform healthcare professionals on optimizing lipid targets for cardiovascular risk reduction.

Main Methods:

  • Literature review of recent clinical guidelines and research.
  • Analysis of different classes of lipid-lowering therapies.
  • Synthesis of evidence on the efficacy and safety of cholesterol management.

Main Results:

  • ASCVD necessitates aggressive lipid management for effective prevention.
  • Multiple classes of cholesterol-lowering agents are available, each with specific indications and benefits.
  • Achieving target lipid levels remains a challenge in clinical practice.

Conclusions:

  • Optimizing lipid management is crucial for reducing ASCVD incidence and mortality.
  • A comprehensive understanding of available cholesterol-lowering agents is essential for personalized patient care.
  • Further efforts are needed to improve treatment adherence and target attainment in patients at risk for ASCVD.