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Naringin nanoparticles against neurodegenerative processes: A preliminary work
Christiane M Nday1, Despoina Eleftheriadou, Graham Jackson
1Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. christiane.nday@yahoo.com, christianen@auth.gr.
Hellenic Journal of Nuclear Medicine
|March 17, 2019
Summary
This study developed novel naringin-encapsulated nanoparticles to combat Alzheimer's disease (AD) neurodegeneration. These nanoparticles show enhanced protection against oxidative stress, offering potential for new brain-targeting therapeutics.
Area of Science:
- Neuroscience
- Biochemistry
- Materials Science
Background:
- Alzheimer's disease (AD) involves neuronal loss, cognitive decline, and oxidative stress, exacerbated by blood-brain barrier alterations.
- Current AD treatments are ineffective, prompting research into natural compounds like flavonoids for neuroprotection.
- Oxidative stress and aging contribute to neurodegeneration and synaptic disruption in AD.
Purpose of the Study:
- To develop enhanced flavonoid-based nanocarriers for potential Alzheimer's disease treatment.
- To encapsulate the flavonoid naringin into modified PEG 3000 Silica nanoparticles.
- To evaluate the neuroprotective effects of these novel nanoparticles in cellular models.
Main Methods:
- Synthesis of PEG 3000 Silica nanoparticles encapsulating naringin.
- Evaluation of physicochemical properties and structural assemblies of the nanoparticles.
- Assessment of nanoparticle neuroprotective capacity against amyloid-beta induced oxidative stress in primary rat hippocampal neuronal and glial cultures.
Main Results:
- Naringin-loaded pegylated nanoparticles demonstrated enhanced protective effects against oxidative stress-mediated neurodegeneration.
- The nanoparticles exhibited unique structural assemblies and physicochemical properties distinct from other drug carriers.
- Successful encapsulation of a high dose of naringin, an otherwise insoluble drug, was achieved.
Conclusions:
- Naringin-loaded PEGylated silica nanoparticles show significant potential as brain-targeting therapeutics for Alzheimer's disease.
- The developed nanocarrier system effectively protects neuronal and glial cells from amyloid-beta induced oxidative stress.
- PEGylation and nanoparticle design are crucial for enhancing the delivery and efficacy of flavonoid-based neuroprotective agents.
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