Review: Using diffusion-weighted magnetic resonance imaging techniques to explore the microstructure and connectivity...

Area of Science:

• Neuroimaging
• Biophysics
• Neuroscience

Background:

• Diffusion-weighted magnetic resonance imaging (dMRI) has been a clinical MRI staple for 30 years.
• dMRI enables in-vivo measurement of anisotropic diffusion, crucial for characterizing tissue microstructure and white matter tract connectivity.
• Existing dMRI research extensively covers various neural networks but notably lacks focus on the auditory brainstem.

Purpose of the Study:

• To review the fundamental principles of dMRI analysis.
• To identify and discuss the challenges in applying dMRI techniques to the auditory brainstem pathways.
• To inform future research by considering current dMRI methodologies relevant to the auditory brainstem.

Main Methods:

• Review of existing literature on dMRI principles and applications.
• Analysis of dMRI methodologies applicable to white matter tract characterization.
• Identification of specific challenges related to auditory brainstem imaging.

Main Results:

• dMRI is a versatile technique for in-vivo diffusion measurement and white matter tract analysis.
• Significant underrepresentation of auditory brainstem research within the dMRI field.
• Specific technical and analytical challenges exist for applying dMRI to the auditory brainstem.

Conclusions:

• There is a need to expand dMRI applications to investigate the auditory brainstem's white matter tracts.
• Addressing the identified challenges is crucial for advancing auditory brainstem research using dMRI.
• This review provides a foundation for future dMRI studies in the auditory brainstem.