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Updated: Jan 27, 2026

Preparation, Purification, and Use of Fatty Acid-containing Liposomes

Preparation, Purification, and Use of Fatty Acid-containing Liposomes

Published on: February 9, 2018

Preparation, microstructure and function of liposome with light responsive switch.

Yangyang Liu¹, Xueqin An¹

¹School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.

Colloids and Surfaces. B, Biointerfaces

|March 17, 2019

Summary

This summary is machine-generated.

Researchers developed novel photo-responsive liposomes using a combined thin film hydration and supercritical carbon dioxide method. These liposomes utilize 4-butylazobenzene-4-hexyloxy-trimethyl-ammoniumtrifluoro-acetate (BHA) as a light-switchable drug release mechanism.

Keywords:

Control release Drug delivery Light responsive switch Liposomes Microstructure Reversibility of structural isomerization

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Last Updated: Jan 27, 2026

Preparation, Purification, and Use of Fatty Acid-containing Liposomes

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Published on: February 9, 2018

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Published on: June 21, 2013

Area of Science:

Materials Science
Nanotechnology
Drug Delivery Systems

Background:

Liposomes are versatile nanocarriers for drug delivery.
Photo-responsive materials offer controlled release capabilities.
Developing stimuli-responsive drug delivery systems is a key research area.

Purpose of the Study:

To prepare novel photo-responsive liposomes.
To investigate the use of 4-butylazobenzene-4-hexyloxy-trimethyl-ammoniumtrifluoro-acetate (BHA) as a photo-responsive switch.
To demonstrate light-controlled drug release from liposomes.

Main Methods:

Combined thin film hydration and supercritical carbon dioxide technique for liposome preparation.
Transmission electron microscopy (TEM) and dynamic light scattering (DLS) for characterization.
Fluorescent probes to investigate liposome microstructure and BHA encapsulation.

Main Results:

Successfully prepared photo-responsive liposomes encapsulating curcumin (model drug) and BHA.
Determined optimal drug incubation temperature based on liposome phase transition temperature.
Confirmed BHA encapsulation within the phospholipid polar head groups of the liposome bilayer.
Demonstrated light-induced structural isomerization of BHA, enabling controlled drug release.

Conclusions:

The developed liposomes exhibit photo-responsiveness and reversibility.
BHA's reversible structural isomerization acts as an effective photo-switch for controlling drug release.
This technology holds potential for advanced, light-triggered therapeutic applications.