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Updated: Jan 27, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

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Elimination of Senescent Cells: Prospects According to the Subtelomere-Telomere Theory

G Libertini1, N Ferrara2, G Rengo2

  • 1Federico II University, Department of Translational Medical Sciences, Naples, 80138, Italy. giacinto.libertini@yahoo.com.

Biochemistry. Biokhimiia
|March 18, 2019
PubMed

Insights

Senolytic compounds eliminate aging cells to combat age-related decline, offering potential benefits but also presenting limitations. Research explores telomerase activation and gene modification alongside senolytics for anti-aging strategies.

Area of Science:

  • Gerontology
  • Cell Biology
  • Molecular Biology

Background:

  • Cell senescence is a reversible state linked to aging, characterized by altered cell function and increased senescent cell accumulation with age.
  • Senescent cells contribute significantly to age-related decline and diseases.
  • The subtelomere-telomere theory provides a framework for understanding programmed aging.

Purpose of the Study:

  • To analyze the potential of senolytic compounds in eliminating senescent cells and reducing aging.
  • To evaluate the efficacy and limitations of senolytic therapy.
  • To compare senolytic therapy with telomerase activation and gene modification strategies.

Main Methods:

  • Review and analysis of existing research on cell senescence and aging.
  • Examination of senolytic compounds and their effects in animal models.
  • Comparative analysis of telomerase activation and gene modification approaches.

Main Results:

  • Senolytic compounds show promise in reducing aging-associated decay in experimental models.
  • Both senolytic elimination and telomerase activation have demonstrated positive effects but also possess inherent limitations.
  • Combined strategies and gene modifications may offer synergistic benefits.

Conclusions:

  • Eliminating senescent cells via senolytics is a promising avenue for anti-aging interventions.
  • Further research is needed to optimize senolytic therapies and explore combined approaches.
  • Ethical considerations are paramount in the development and application of these anti-aging strategies.

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