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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-III: Symptoms and Complications01:24

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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Asthma-IV: Nursing Management01:30

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Severe asthma in Japan.

Hiroyuki Nagase1

  • 1Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|March 18, 2019
PubMed
Summary
This summary is machine-generated.

Japanese severe asthma is characterized by low obesity rates and high type 2 inflammation prevalence. Biomarker research aids in identifying severe asthma phenotypes, potentially explaining lower disease burden in Japan.

Keywords:
BiologicsJapaneseObesitySevere asthmaType 2 inflammation

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Area of Science:

  • Pulmonology
  • Immunology
  • Epidemiology

Background:

  • Severe asthma in Japan presents a distinct phenotype compared to Western countries.
  • Key features include a low incidence of obesity and a high prevalence of type 2 inflammation.

Purpose of the Study:

  • To review the definition, epidemiology, comorbidities, biomarkers, and treatment of severe asthma in Japan.
  • To explore the unique characteristics of severe asthma in the Japanese population.

Main Methods:

  • Review of existing literature and cohort studies on severe asthma in Japan.
  • Analysis of epidemiological data, biomarker utility, and treatment strategies.

Main Results:

  • Over 80% of Japanese severe asthma patients exhibit type 2 inflammation, with obesity (BMI ≥30 kg/m²) in only 5-7%.
  • Type 2 biomarkers, like periostin, are investigated for identifying exacerbation-prone subgroups.
  • Lower asthma mortality and disease burden in Japan may be linked to universal healthcare and accessibility.

Conclusions:

  • The distinct phenotype of severe asthma in Japan, marked by low obesity and high type 2 inflammation, warrants specific diagnostic and therapeutic approaches.
  • Biomarker combinations show promise for precise phenotyping and management of severe asthma.
  • Japan's healthcare system may contribute to better outcomes in severe asthma patients.