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Updated: Jan 27, 2026

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
Published on: June 6, 2020
Plant cell surface immune receptor complex signaling
Wei-Lin Wan1, Katja Fröhlich1, Rory N Pruitt1
1Department of Plant Biochemistry, Centre for Plant Molecular Biology (ZMBP), Eberhard Karls University Tübingen, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
Abstract:
Plant plasma membrane pattern recognition receptors are key to microbe sensing and activation of immunity to microbial invasion. Plants employ several types of such receptors that differ mainly in the structure of their ectodomains and the presence or absence of a cytoplasmic protein kinase domain. Plant immune receptors do not function as single entities, but form larger complexes which undergo compositional changes in a ligand-dependent manner. Here, we highlight current knowledge of molecular mechanisms underlying receptor complex dynamics and regulation, and cover early signaling networks implicated in the activation of generic plant immune responses. We further discuss how an increasingly comprehensive set of immune receptors may be employed to engineer crop plants with enhanced, durable resistance to microbial infection.
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