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Updated: Jan 27, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Secondary thyroid malignancy from metastatic colon lymphoma.
Cristian Marco-Alacid1,2, Mario López-Merseguer1,2, Carlos Sánchez-Juan1,2
1Unidad de Endocrinología y Nutrición, Consorci Hospital General Universitari de València, Valencia, Comunitat Valenciana, Spain.
Thyroid cancer is usually primary, but this case shows rare colon lymphoma metastasis to the thyroid. Imaging like PET-CT requires ultrasound and fine needle aspiration for accurate diagnosis and treatment.
Area of Science:
- Oncology
- Endocrinology
- Radiology
Background:
- Primary thyroid malignancies are more common than secondary metastases.
- Thyroid metastases are rare, with varied origins.
- Accurate diagnosis is crucial for appropriate patient management.
Observation:
- A case of colon lymphoma presenting with an unusual thyroid metastasis is described.
- A thyroid lesion detected on 18F-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography-Computed Tomography (FDG-PET-CT) prompted further investigation.
- Ultrasound and fine needle aspiration biopsy were utilized for detailed assessment.
Findings:
- The thyroid lesion was confirmed to be a metastasis from colon lymphoma, a rare occurrence.
- Integrated imaging and cytologic analysis enabled precise diagnosis.
- The diagnostic pathway successfully differentiated the secondary malignancy from primary thyroid cancer.
Implications:
- Highlights the importance of considering extranodal lymphoma metastasis to the thyroid.
- Emphasizes the utility of ultrasound and fine needle aspiration in evaluating incidental thyroid findings on PET-CT.
- Guides diagnostic and therapeutic strategies for rare metastatic presentations in the thyroid gland.
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