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Updated: Jan 27, 2026
09:49
Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
Published on: August 13, 2010
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Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study
Irina Gasslitter1, Natalia Kirsten2, Matthias Augustin2
1Department of Internal Medicine II, University of Innsbruck, Innsbruck, Austria.
Archives of Dermatological Research
|March 18, 2019
Summary
Switching between interleukin-17 (IL-17) blockers is a viable option for psoriasis patients. Over half of patients achieved significant skin clearance (PASI 75) after switching anti-IL-17 therapies.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Interleukin-17 (IL-17) blockers represent novel therapies for psoriasis.
- Limited data exists on the efficacy of switching between different IL-17 inhibitors.
Purpose of the Study:
- To evaluate the treatment response in patients with moderate-to-severe psoriasis who switched between IL-17 blockers.
- To assess the effectiveness of interclass switching among secukinumab, ixekizumab, and brodalumab.
Main Methods:
- Retrospective, multi-center study involving 26 patients with psoriasis.
- Patients switched from one IL-17 blocker to another due to unsatisfactory response.
- Treatment success defined as PASI 75 response after 12 weeks.
Main Results:
- 52% of patients achieved PASI 75 after switching IL-17 blockers.
- An additional 20% achieved PASI 50.
- No treatment success was observed in 28% of patients.
Conclusions:
- Switching to another IL-17 blocker is a promising strategy for patients with inadequate response or intolerance.
- Further research with larger cohorts is necessary to validate these findings.
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