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Updated: Jan 27, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
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Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery

Erin Morgan1, John T Gamble2, Martin C Pearce2

  • 1Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA. emorgan@chem.ucsb.edu.

Apoptosis : an International Journal on Programmed Cell Death
|March 18, 2019
PubMed

Insights

This study introduces a novel light-activated drug delivery system using hollow gold nanoshells to deliver a peptide, enhancing cancer therapy efficacy and overcoming chemoresistance in lung cancer models.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapeutics

Background:

  • Developing effective cancer therapeutics faces challenges in drug delivery and chemoresistance.
  • Targeted delivery systems are crucial for improving treatment outcomes.
  • Bcl-2 proteins play a role in cancer cell survival.

Purpose of the Study:

  • To develop a light-activated delivery method for a Bcl-2 functional converting peptide (NuBCP-9).
  • To address limitations of current cancer therapeutics, including delivery and chemoresistance.
  • To evaluate the efficacy of NuBCP-9 delivered via hollow gold nanoshells.

Main Methods:

  • Utilized hollow gold nanoshells for light-activated drug delivery.
  • Employed a Bcl-2 functional converting peptide, NuBCP-9.
  • Tested the system in vitro and in a paclitaxel-resistant H460 lung xenograft model.

Main Results:

  • Achieved a 30-fold increase in peptide efficacy in vitro.
  • Demonstrated a 56.4% reduction in paclitaxel-resistant H460 lung xenograft tumor growth.
  • Validated the dual action of enhanced delivery and overcoming chemoresistance.

Conclusions:

  • Light-activated delivery of NuBCP-9 using hollow gold nanoshells is a promising strategy for cancer treatment.
  • This method effectively enhances therapeutic efficacy and combats chemoresistance.
  • The approach holds potential for improving outcomes in challenging cancer cases.
Keywords:
ApoptosisBcl-2Hollow gold nanoshellsNuBCPPeptide deliveryResistant cancer

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