Related Experiment Video
Updated: Jan 27, 2026
09:44
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
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Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes
Kayleen Bailey1, Neeta Pandit-Taskar2, John L Humm3
1Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.
Journal of Neuro-Oncology
|March 18, 2019
Summary
Intraventricular iodine-131-omburtamab (131I-Omburtamab) targeting B7-H3 shows safety and potential therapeutic benefit in patients with ependymoma (ETMR). This targeted therapy, used after surgery and chemoradiation, may improve outcomes for ETMR patients.
Area of Science:
- Oncology
- Radiopharmaceuticals
- Immunotherapy
Background:
- Ependymoma (ETMR) is a rare central nervous system tumor.
- B7-H3 is an antigen expressed on ETMR cells.
- Intraventricular therapy offers targeted delivery to CNS tumors.
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