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Understanding CGRP and Cardiovascular Risk
Eloísa Rubio-Beltrán1, Antoinette Maassen van den Brink2
1Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Handbook of Experimental Pharmacology
|March 18, 2019
Summary
Calcitonin gene-related peptide (CGRP) antibodies target migraine, but CGRP
Area of Science:
- Neurology
- Cardiovascular Science
Background:
- Calcitonin gene-related peptide (CGRP) plays a key role in migraine pathophysiology.
- CGRP is also involved in various physiological processes and homeostatic responses.
- Migraine patients have an increased risk of cardiovascular events like stroke and myocardial infarction.
Purpose of the Study:
- To discuss the potential risks of long-term CGRP pathway blockade.
- To focus on the cardiovascular system's response to CGRP inhibition.
Main Methods:
- Literature review and analysis of existing studies on CGRP function and cardiovascular effects.
Main Results:
- CGRP has a demonstrated protective role during ischemic events.
- Long-term CGRP blockade may pose risks, particularly to the cardiovascular system.
Conclusions:
- The widespread physiological roles of CGRP necessitate careful consideration of long-term blockade risks.
- Further research is needed to fully understand the cardiovascular implications of CGRP-targeted therapies.
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