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Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity
Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1986
Summary
Exercise intensity influences coagulation and fibrinolysis. The fibrinolytic system activates earlier than factor VIII complex changes during exercise, linked to increased lactate and hydrogen ions.
Area of Science:
- Exercise physiology
- Hemostasis
- Fibrinolysis
Background:
- Exercise impacts the coagulation and fibrinolytic systems.
- The relationship between exercise intensity, duration, and these systems is not fully understood.
Purpose of the Study:
- To examine how exercise duration and intensity affect the factor VIII complex and fibrinolytic system.
- To determine the sequence of activation between these systems during exercise.
Main Methods:
- Five healthy males underwent three exercise protocols: graded to exhaustion, steady-state, and maximal 30-s tests.
- Blood samples were collected at baseline, during exercise, and for 1 hour post-exercise.
- Analyzed factor VIII components, fibrinolytic activity (clot lysis time), lactate, and pH.
Main Results:
- Factor VIII components increased only at the highest exercise intensities.
- Whole blood clot lysis time shortened earlier, even at low work intensities.
- No qualitative changes in factor VIII-related antigen or evidence of thrombin generation were found.
Conclusions:
- Exercise-induced changes in coagulation and fibrinolysis are intensity-dependent, correlating with plasma lactate and pH.
- Fibrinolytic system activation precedes observed changes in the factor VIII complex during exercise.