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Predictive and Comparative Study Between Clinic Consensus Document for Pancreas Acceptance and Predictive Value of
C Rodríguez-Villar1, D Paredes1, R Roque1
1Donation and Transplant Coordination Section, Hospital Clinic, Barcelona, Spain.
Transplantation Proceedings
|March 19, 2019
Summary
The Clinical Consensus Document (CCD) criteria for pancreas transplantation resulted in 7 more transplants than the Preprocurement Pancreas Allocation Suitability Score (P-PASS). The CCD criteria are more effective for selecting suitable pancreas donors.
Area of Science:
- Transplantation immunology
- Organ procurement and allocation
- Surgical outcomes
Background:
- Strict selection of pancreases for transplantation is crucial to minimize risks and complications.
- Established criteria include Eurotransplant's Preprocurement Pancreas Allocation Suitability Score (P-PASS) from 2008 and the Hospital Clinic of Barcelona's Clinical Consensus Document (CCD) from 2001.
Purpose of the Study:
- To analyze the predictive accuracy of pancreas acceptance decisions based on CCD criteria.
- To compare the CCD criteria with the P-PASS suitability score for pancreas acceptance.
Main Methods:
- A retrospective comparative study was conducted.
- Pancreas selection criteria from the CCD (2016-2017) were compared against P-PASS values.
- Organs were classified as rejected or accepted, with accepted organs potentially being procured and transplanted or discarded.
Main Results:
- The CCD criteria led to the transplantation of 7 additional pancreases compared to using P-PASS criteria alone.
- P-PASS criteria would have excluded an additional 9% of pancreases compared to the CCD criteria.
Conclusions:
- Developing accurate prediction models for pancreas selection remains challenging.
- The application of CCD criteria increases the number of viable pancreases for transplantation.
- Further re-evaluation of selection criteria within multicenter studies is warranted.
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