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Updated: Jan 27, 2026

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
08:15

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

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543

Contamination of the Preservation Solution in Solid Organ Transplantation

G C Sotiropoulos1, I D Kostakis1, A Prodromidou1

  • 12nd Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

Transplantation Proceedings
|March 19, 2019
PubMed
Abstract

Insights

Microbial contamination of preservation solutions (PS) in liver transplantation is common, affecting 25% of patients. However, data on transmission to recipients and subsequent infections remain limited, necessitating further research.

Area of Science:

  • Transplantation medicine
  • Microbiology
  • Infectious diseases

Background:

  • Preservation solutions (PS) used in liver transplantation can support microorganism growth.
  • Contaminated PS may transmit pathogenic germs to transplant recipients.

Purpose of the Study:

  • To review the literature on the incidence and predictors of positive microbiological findings in PS.
  • To assess the impact of PS contamination on recipient bacteremia and nosocomial infections.

Main Methods:

  • Systematic literature review of studies on bacterial and fungal contamination of PS.
  • Focus on studies published between 2000 and 2016, encompassing 5647 patients.

Main Results:

  • Positive cultures in PS were found in 25% of reviewed cases (1428/5647).
  • Bacteremia rates varied widely (0%–69%).
  • Data on pathogen transmission and related nosocomial infections were sparse (0%–8% for same species, 0%–19% for infections).

Conclusions:

  • Limited and contradictory data exist regarding PS contamination in solid organ transplantation.
  • Current evidence does not support specific recommendations.
  • Prospective, multicentric studies are essential to address this knowledge gap.

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