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A Paradigm Shift in the Management of Cherubism? A Preliminary Report Using Imatinib
Pat Ricalde1, Imran Ahson2, Samantha T Schaefer3
1Director, Florida Craniofacial Institute, Tampa, FL.
Abstract:
Cherubism is an autosomal-dominant inherited mutation in the SH3BP2 gene on chromosome 4p16.3. It is characterized by bilateral symmetric fibro-osseous lesions that are limited to the maxilla and mandible. The lesions present in early childhood and typically spontaneously involute after puberty. Current standard practice is to reserve surgery for symptomatic or severely disfiguring cases. This report presents 3 patients with cherubism who exhibited marked reduction in tumor size with imatinib, a tyrosine kinase inhibitor. Treatment was well tolerated, with few side effects.
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