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Respirometric Oxidative Phosphorylation Assessment in Saponin-permeabilized Cardiac Fibers
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Oxidative phosphorylation inducers fight pathological angiogenesis

M Pilar Bayona-Bafaluy1, Olivia Esteban2, Javier Ascaso2

  • 1Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain; Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Spain.

Drug Discovery Today
|March 19, 2019
PubMed
Summary

Dysfunctional oxidative phosphorylation (OXPHOS) increases vascular endothelial growth factor (VEGF) and pathological angiogenesis. Enhancing OXPHOS function may offer a therapeutic strategy for angiogenesis-related diseases.

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