Deciphering polymyxin B minimum inhibitory concentration from colistin minimum inhibitory concentration and vice
Bijayini Behera1, Jayanti Jena1, Punyatoya Kar1
1Department of Microbiology, AIIMS, Bhubaneswar, Odisha, India.
Abstract:
The susceptibility determination to polymyxins (colistin and polymyxin B) remains a challenge for clinical microbiology laboratories. We evaluated the minimum inhibitory concentration (MIC) of both antimicrobials by the broth microdilution method in a selected subset of 156 carbapenem-resistant Enterobacteriaceae (CRE) isolates. Good concordance between polymyxin B and colistin MIC values was obtained, and there was 98% categorical agreement in CRE isolates. Future large-scale multicentre study is needed to draw conclusion if the MIC of colistin can be used to extrapolate the MIC of polymyxin B and vice versa.
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