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Updated: Jan 27, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
Published on: August 4, 2011
Prevalence of refractive errors in children with retinoblastoma
Victor M Villegas1,2, Shuo-Chieh Wu1, Timothy G Murray2
1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, FL, USA, v.villegas@med.miami.edu.
Purpose:
The main purpose of this study was to investigate refractive errors in children with unilateral and bilateral retinoblastoma (RB).
Methods:
An institutional review board-approved consecutive retrospective cohort study was undertaken. Subjects underwent examination under general anesthesia as part of their RB follow-up, which included evaluation by a single pediatric ophthalmologist. Cycloplegic retinoscopy was performed and keratometry data assessed with a handheld Retinomax K Plus 3 keratorefractometer (Righton Ophthalmic Instruments).
Results:
The study included 61 eyes of 37 subjects, with 18 (49%) males and 19 females. Seventeen eyes (28%) had hyperopia with spherical equivalent ≥3 D. Refractive astigmatism ≥1.5 D was present in 32% of all eyes. Nine (38%) subjects had anisometropia ≥2 D. Fifteen (63%) subjects had anisometropia ≥1 D.
Conclusion:
This study reports the high proportion of amblyogenic refractive risk factors in children with RB, both in RB-affected eyes and contralateral normal eyes.
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