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Updated: Jan 27, 2026
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Determination of the Spontaneous Locomotor Activity in Drosophila melanogaster
Published on: April 10, 2014
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Disrupted resting-state spontaneous neural activity in stable COPD.
Huizhen Xin1, Haijun Li1, Honghui Yu1
1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, People's Republic of China, pengdcdoctor@163.com.
Summary
Patients with Chronic Obstructive Pulmonary Disease (COPD) exhibit reduced local brain synchronization, particularly in visual processing areas. This altered brain activity correlates with disease severity and cognitive function, offering insights into COPD-related cognitive impairment.
Area of Science:
- Neuroscience
- Pulmonology
- Radiology
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is associated with known brain structural and functional changes detected via MRI.
- Local synchronization deficits in spontaneous brain activity in stable COPD patients remain largely uncharacterized.
Purpose of the Study:
- To investigate spontaneous brain activity using regional homogeneity (ReHo) in stable COPD patients compared to healthy controls.
- To explore the relationship between altered brain activity and clinical/neuropsychological parameters in COPD.
Main Methods:
- Resting-state functional MRI (fMRI) was performed on 19 COPD patients and 20 healthy controls.
- Regional homogeneity (ReHo) analysis assessed local brain signal synchrony.
- Receiver operating characteristic (ROC) curve analysis and Pearson's correlation were used for evaluation.
Main Results:
- COPD patients showed significantly lower ReHo values in the left occipital lobe, right lingual gyrus, bilateral precuneus, and right precentral gyrus.
- Altered ReHo values demonstrated high efficacy in distinguishing function via ROC analysis.
- Lower ReHo in the precuneus correlated positively with FEV1% and negatively with arterial partial pressure of carbon dioxide.
Conclusions:
- COPD patients exhibit abnormal regional spontaneous brain activity synchrony.
- Affected brain regions are linked to visual processing pathways.
- Findings suggest a novel perspective on the pathophysiology of cognitive impairment in COPD.
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