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Updated: Jan 27, 2026

Organotypic Retinal Explant Cultures from Macaque Monkey
Published on: August 24, 2022
Identification of Hepatocystis species in a macaque monkey in northern Myanmar
Qiaocheng Chang1, Xiaodong Sun2, Jian Wang2
1Key Laboratory of Zoonosis, Jilin University, Changchun, qijun.chen@ipbcams.ac.cn, jiangning@jlu.edu.cn.
Background:
Long-tailed and pig-tailed macaque monkeys are natural hosts of Plasmodium knowlesi, which has been identified as a fifth malaria parasite infecting humans. In this study, we investigated possible infection by this Plasmodium parasite in macaque monkeys using a combination of polymerase chain reaction amplification and sequencing.
Methods:
Forty-five blood samples were obtained in 2010 from macaques in northern Myanmar near Yunnan Province of China and investigated for possible infection with Plasmodium species using a nested polymerase chain reaction method for amplification of 18S SSU rRNA genes.
Results:
Positive amplification was obtained from one monkey, and both sequence and phylogenetic analysis indicated that the parasite was of the Hepatocystis species lineage.
Conclusion:
The results suggest that a combination of polymerase chain reaction amplification and sequence identification would be necessary for detection of Plasmodium knowlesi infection in both humans and its natural hosts.
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