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MicroRNAs in Alzheimer's Disease
Mengli Wang1, Lixia Qin1, Beisha Tang1,2,3,4,5
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Frontiers in Genetics
|March 19, 2019
Summary
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss. This review highlights how microRNAs are critical in AD pathogenesis and progression.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- Alzheimer's disease (AD) is a leading cause of dementia, characterized by memory loss and cognitive impairment.
- AD pathogenesis involves amyloid plaques and neurofibrillary tangles, with unknown causes and no available cure.
- The growing aging population exacerbates the societal and economic burden of AD.
Purpose of the Study:
- To review the critical role of microRNAs in Alzheimer's disease pathogenesis.
- To highlight the impact of microRNAs on various pathological processes during AD progression.
Main Methods:
- Literature review focusing on microRNA research in Alzheimer's disease.
- Analysis of microRNA's regulatory role in gene expression at the post-transcriptional level.
Main Results:
- MicroRNAs are key regulators of gene expression involved in numerous biological processes.
- Accumulating evidence indicates microRNAs play a significant role in the multifactorial pathogenesis of AD.
- MicroRNAs are implicated in various pathological processes throughout the progression of Alzheimer's disease.
Conclusions:
- MicroRNAs are crucial in understanding Alzheimer's disease mechanisms.
- Targeting microRNAs may offer novel therapeutic strategies for AD.
- Further research into microRNA's role is essential for developing effective AD treatments.