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Association between serum adropin level and coronary artery disease: a systematic review and meta-analysis

Jiankang Zheng1,2, Mao Liu2,3, Ling Chen2,3

  • 1Department of Clinical Medicine, North Sichuan Medical College, Nanchong 637100, China.

Cardiovascular Diagnosis and Therapy
|March 19, 2019
PubMed

Insights

Serum adropin levels are significantly lower in patients with coronary artery disease (CAD). This finding suggests that reduced adropin may contribute to the development of CAD, impacting cardiovascular health.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Research

Background:

  • Emerging research links adropin to coronary artery disease (CAD).
  • Adropin is a peptide hormone with potential roles in cardiovascular regulation.
  • Understanding adropin's role in CAD is crucial for developing new diagnostic and therapeutic strategies.

Purpose of the Study:

  • To systematically evaluate the association between serum adropin levels and CAD.
  • To synthesize evidence from multiple studies to determine the overall relationship.
  • To investigate adropin levels across different CAD subtypes, including acute myocardial infarction (AMI), unstable angina pectoris (UAP), and stable angina pectoris (SAP).

Main Methods:

  • Comprehensive literature search of major scientific databases (Cochrane Library, PubMed, EMbase, etc.).
  • Inclusion of seven clinical studies with a total of 945 participants.
  • Meta-analysis using Standard Mean Difference (SMD) and 95% confidence intervals (CI) performed with RevMan 5.2 software.

Main Results:

  • Serum adropin levels were significantly lower in patients with CAD compared to healthy controls (SMD = -2.44, P = 0.0008).
  • Subgroup analyses revealed lower adropin levels in patients with AMI (SMD = -2.96, P < 0.00001), UAP (SMD = -2.09, P = 0.0001), and SAP (SMD = -1.23, P = 0.007).
  • Consistent reduction in adropin observed across all CAD patient groups.

Conclusions:

  • Patients with coronary artery disease exhibit lower serum adropin concentrations than healthy individuals.
  • A decrease in adropin levels may play a significant role in the pathogenesis of CAD.
  • Adropin may serve as a potential biomarker for CAD risk stratification and management.
Abstract

Keywords:
Adropincoronary artery disease (CAD)meta-analysis

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