[Detection of isoimmune antibodies against a population of human B-lymphocytes]

Rosette-forming ability of human lymphocytes was tested before and after their sensitization with isoimmune sera against histocompatibility antigens. Anti-HLA sera inhibited the ability of T- and B- lymphocyteè to form rosettes. Some sera inhibited rosette formation mostly of B-lymphocytes; they also possessed marked capacity to react with B-lymphocytes population in prolonged lymphotoxic tests.