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Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies

Carolina Argondizo-Correia1,2, Ana Kelly Sousa Rodrigues2, Cyro Alves de Brito1,2

  • 1Institute of Tropical Medicine, University of São Paulo, Dr. Enéas de Carvalho Aguiar Avenue 470 Jardim América, São Paulo, SP 05403-000, Brazil.

Journal of Immunology Research
|March 19, 2019
PubMed

Insights

Whooping cough (pertussis) is reemerging, especially in newborns. New strategies are needed to protect infants, as current vaccines and herd immunity are insufficient for this vulnerable population.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Public Health

Background:

  • Pertussis, caused by *Bordetella pertussis*, is a reemerging infectious disease.
  • Newborns are highly susceptible to severe pertussis due to immature immune systems and inability to be vaccinated.
  • Current vaccination strategies, including infant vaccination and herd immunity, are insufficient to curb rising pertussis cases.

Purpose of the Study:

  • To address the reemergence of pertussis (whooping cough).
  • To investigate strategies for protecting newborns against *Bordetella pertussis* infection.
  • To overcome limitations of early-life immune responses for effective pertussis vaccination.

Main Methods:

  • Analysis of *Bordetella pertussis* epidemiology.
  • Evaluation of infant immune system development and vaccine responses.
  • Exploration of novel vaccination approaches for vulnerable infants.

Main Results:

  • High vaccine coverage has not prevented pertussis resurgence.
  • Newborns exhibit unique immune system characteristics increasing susceptibility and mortality.
  • Existing prevention methods are inadequate for protecting the youngest infants.

Conclusions:

  • Enhanced strategies are crucial to protect newborns from pertussis.
  • Overcoming developmental immune differences in infants is key to effective protection.
  • New approaches are needed to induce immunity in infants during their most vulnerable period.

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