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Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor
Matthew A Pettengill1,2, Tara M Babu1, Paritosh Prasad1
1University of Rochester Medical Center, Rochester, New York.
Abstract:
Human adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1.
Insights
Human adenovirus type 34 (HAdV-34) infection can cause serious kidney issues in transplant patients. This study highlights two cases of HAdV-34 causing nephritis, likely acquired from the same organ donor.
Area of Science:
- Transplant Medicine
- Virology
- Nephrology
Background:
- Human adenovirus type 34 (HAdV-34) is a known cause of transplant-associated hemorrhagic cystitis.
- HAdV-34 can also lead to tubulointerstitial nephritis in rare instances.
- Determining the source of HAdV-34 infection post-transplant is challenging.
Purpose of the Study:
- To report two cases of HAdV-34 infection in transplant recipients.
- To investigate the likely source of HAdV-34 infection in these cases.
- To describe the clinical manifestation of HAdV-34-induced tubulointerstitial nephritis.
Main Methods:
- Case report of two transplant recipients.
- Clinical data review.
- Infection source investigation.
Main Results:
- Two patients developed HAdV-34 infection.
- One patient presented with tubulointerstitial nephritis.
- Both infections were likely acquired from the same organ donor.
Conclusions:
- HAdV-34 can manifest as tubulointerstitial nephritis post-transplantation.
- Organ donor transmission is a potential route for HAdV-34 acquisition.
- Further investigation into HAdV-34 transmission in transplantation is warranted.
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