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Updated: Jan 27, 2026
09:43
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
Published on: October 31, 2013
14.2K
Translocation of tetrahedral DNA nanostructures through a solid-state nanopore
Xinjia Zhao1, Ruiping Ma, Ying Hu
1Beijing National Laboratory for Condensed-Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China. xhlu@aphy.iphy.ac.cn shanxinyan@aphy.iphy.ac.cn.
Nanoscale
|March 19, 2019
Summary
Tetrahedral DNA nanostructures (TDNs) show distinct signals when passing through nanopores. This DNA nanotechnology can detect specific DNA segments in real-time using solid-state nanopore devices.
Area of Science:
- Nanotechnology
- Biophysics
- Molecular Biology
Background:
- Tetrahedral DNA nanostructures (TDNs) are versatile programmable nanomaterials.
- TDNs have potential applications in biosensing, cell imaging, and therapeutics.
Purpose of the Study:
- To investigate the translocation behavior of individual TDNs through solid-state nanopores.
- To assess the sensitivity of TDN translocation signals to nanostructure size and binding configurations.
Main Methods:
- Utilizing solid-state nanopore devices to monitor ionic current changes.
- Analyzing translocation signals generated by individual TDNs.
- Statistically analyzing the temporal positions of TDNs bound to linear DNA molecules.
Main Results:
- Observed pronounced and size-sensitive translocation signals for TDNs.
- Detected unique signals for TDNs bound to linear DNA, differentiating end-bound from middle-bound configurations.
- Identified characteristic current traces for multiple TDNs on a single DNA molecule.
Conclusions:
- TDNs exhibit unique translocation signatures through nanopores.
- Solid-state nanopore technology can differentiate TDN binding states on DNA.
- TDNs show promise as sensitive real-time biosensors for specific DNA segments.
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