Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T cell differentiation within thymic nurse cells.

R de Waal Malefijt, W Leene, P J Roholl

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Electron microscopy of bone.

    Methods in cell biology·2013
    Same author

    [Spontaneous dental abscesses in familial hypophosphatemic rickets].

    Nederlands tijdschrift voor tandheelkunde·2012
    Same author

    Rapid combined light and electron microscopy on large frozen biological samples.

    Journal of microscopy·2009
    Same author

    Pathogenesis of poliovirus infection in PVRTg mice: poliovirus replicates in peritoneal macrophages.

    The Journal of general virology·2003
    Same author

    Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells.

    Cancer gene therapy·2001
    Same author

    The adventitia of atherosclerotic coronary arteries frequently contains Chlamydia pneumoniae.

    Atherosclerosis·2001
    Same journal

    Changes in Three-Dimensional Intrahepatic Biliary Structures in Patients With Hepatobiliary Diseases Visualized Using Tissue-Clearing Methods.

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Genome-wide SNP-based Profiling of Loss of Heterozygosity Reveals Distinct Molecular Subgroup-specific Patterns in Gastrointestinal Stromal Tumors (GIST).

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    AI-Assisted HER2 Scoring in Breast Cancer: Diagnostic Agreement and Understanding Discordance.

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Corrigendum to "POU2F3 in Small Cell Lung Cancer (SCLC): Diagnostic Utility in Neuroendocrine-Low/Negative SCLC and Discrimination From Other Thoracic Malignancies and Other Small Blue Round Cell Tumors" [Laboratory Investigation 2026;106(6):106124].

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Assessing the Effects of a 3D Pathology Tissue-Processing Workflow on Downstream Molecular Analyses.

    Laboratory investigation; a journal of technical methods and pathology·2026
    Same journal

    Transcription Factor Ets-1 Is a Central Regulator of Redox Balance and Liver Regeneration Through epidermal growth factor (EGF) and transforming growth factor-β (TGF-β) 1 Signaling.

    Laboratory investigation; a journal of technical methods and pathology·2026
    See all related articles

    Thymic nurse cells (TNCs) contain immature and mature thymocytes, suggesting their crucial role in T cell selection and differentiation within the thymus microenvironment.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Thymic nurse cells (TNCs) are epithelial cells in the thymus that encapsulate developing T cells (thymocytes).
    • TNCs express major histocompatibility complex (MHC) antigens on their surface.

    Purpose of the Study:

    • To investigate the expression of MHC antigens on the vacuolar membranes of TNCs.
    • To analyze the T cell differentiation antigens and cortisone resistance of thymocytes within TNCs.

    Main Methods:

    • Utilized an improved in situ labeling technique to examine MHC and T cell differentiation antigen expression.
    • Correlated antigen expression with cortisone sensitivity to determine thymocyte maturation status.

    Main Results:

    • Vacuolar membranes of TNCs exhibit the same MHC phenotype (H-2 K/D+, I-A2+) as the TNC plasma membrane.

    Related Experiment Videos

  • The majority of TNC thymocytes are cortisone-sensitive with an immature cortical phenotype (Thy-1hi, PNAhi).
  • A minority of TNC thymocytes are cortisone-resistant with a mature phenotype (Thy-1lo, PNAlo).

    • Conclusions:

    • TNCs provide an MHC-positive microenvironment crucial for T cell development.
    • The heterogeneity of thymocytes within TNCs, based on maturation and cortisone resistance, highlights their role in T cell selection and differentiation.