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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Ganciclovir Therapeutic Drug Monitoring: A Case Series

Anne-Grete Märtson1, Daan Touw1, Kevin Damman2

  • 1Departments of Clinical Pharmacy and Pharmacology.

Therapeutic Drug Monitoring
|March 19, 2019
PubMed

Insights

Therapeutic drug monitoring of ganciclovir, combined with cytomegalovirus viral load testing, effectively guided treatment in three immunocompromised patients. This approach aids in managing complex cytomegalovirus infections in diverse patient populations.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Immunology

Background:

  • Cytomegalovirus (CMV) infections pose significant risks in immunocompromised individuals.
  • Ganciclovir is a primary antiviral agent used for CMV treatment.
  • Effective management requires balancing efficacy with potential toxicity.

Observation:

  • Three distinct cases of immunocompromised patients (thymoma, heart transplant, HIV+) with CMV infection are presented.
  • These patients received ganciclovir treatment.
  • Treatment decisions were informed by therapeutic drug monitoring (TDM) of ganciclovir levels and CMV viral load.

Findings:

  • TDM of ganciclovir, alongside CMV viral load monitoring, provided crucial data for optimizing antiviral therapy.
  • Personalized dosing strategies based on TDM were implemented.
  • Successful management of CMV infection was achieved in all three complex cases.

Implications:

  • Therapeutic drug monitoring is a valuable tool for optimizing ganciclovir therapy in immunocompromised patients.
  • This integrated approach can improve clinical outcomes for CMV infections.
  • Case studies highlight the utility of TDM in managing challenging patient scenarios.

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