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Pain mechanisms in hereditary palmoplantar keratodermas
R L Weinberg1,2,3, P A Coulombe4,5, M Polydefkis6
1Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, 21205, U.S.A.
The British Journal of Dermatology
|March 19, 2019
Summary
Pain is a significant issue in hereditary palmoplantar keratodermas (PPKs), affecting quality of life. This review explores the varied pain mechanisms in PPKs, suggesting targeted treatments may be possible.
Area of Science:
- Dermatology
- Pain Medicine
- Genetics
Background:
- Palmoplantar keratodermas (PPKs) are a group of genetic skin disorders causing epidermal thickening on hands and feet.
- These conditions often lead to significant palmoplantar pain, impacting patients' quality of life.
Purpose of the Study:
- To review the scope of pain in hereditary PPKs.
- To identify potential mechanisms underlying this pain.
- To synthesize current knowledge on PPK pain with broader pain mechanisms.
Main Methods:
- Literature review focusing on hereditary PPKs.
- Analysis of pain incidence, nature, and underlying mechanisms.
- Synthesis of findings with general pain mechanisms.
Main Results:
- Pain is a major, yet poorly understood and treated, symptom in many hereditary PPKs.
- Pain prevalence and presentation vary across different PPK types, suggesting diverse underlying mechanisms.
- Potential pain mechanisms include structural issues (fissures, blisters), infections, inflammation, and neuropathic alterations.
Conclusions:
- Understanding the diverse pain mechanisms in PPKs is crucial for developing targeted treatments.
- Further research into neuropathic and inflammatory pathways could lead to improved pain management strategies.
- Addressing the heterogeneity of pain in PPKs is key to enhancing patient quality of life.
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