Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Small Populations02:04

Conservation of Small Populations

17.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.1K
What is Population Genetics?01:25

What is Population Genetics?

64.6K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.6K
Population Growth00:57

Population Growth

28.3K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.3K
Association Areas of the Cortex01:21

Association Areas of the Cortex

9.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.2K
Associative Learning01:27

Associative Learning

1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
What are Populations and Communities?00:30

What are Populations and Communities?

37.6K
Overview
37.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population discontinuity in the Paris Basin linked to evidence of the Neolithic decline.

Nature ecology & evolution·2026
Same author

Flexible read-aware genotype imputation from sequence using biobank sized reference panels.

Nature communications·2025
Same author

SVUPP: Pre-phasing long reads improves structural variant genotyping.

Bioinformatics (Oxford, England)·2025
Same author

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.

Nature communications·2025
Same author

SimOutbreakSelection: a simulation-based tool to optimise sampling design and analysis strategies for detecting epidemic-driven selection.

Nature communications·2025
Same author

Picuris Pueblo oral history and genomics reveal continuity in US Southwest.

Nature·2025

Related Experiment Video

Updated: Jan 27, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.8K

Ancestry-specific association mapping in admixed populations.

Line Skotte1, Emil Jørsboe2, Thorfinn S Korneliussen3

  • 1Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.

Genetic Epidemiology
|March 19, 2019
PubMed
Summary

This study introduces a new statistical method for genetic association testing in admixed populations. The approach enhances power to detect disease variants by allowing effect sizes to vary by ancestry.

Keywords:
GWASadmixtureassociation mappinglocal ancestrypower

More Related Videos

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K

Related Experiment Videos

Last Updated: Jan 27, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.8K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K

Area of Science:

  • Genetics
  • Population Genetics
  • Statistical Genetics

Background:

  • Genome-wide association studies (GWAS) are powerful for identifying disease variants.
  • Current GWAS methods assume consistent variant effects across ancestral populations, which may not hold for non-causal variants in admixed groups due to varying linkage disequilibrium and allele frequencies.

Purpose of the Study:

  • To develop a novel statistical method for association testing in recently admixed populations.
  • To allow genetic variant effect sizes to be dependent on allele ancestry.
  • To increase statistical power for detecting associations and differentiate causal from non-causal variants.

Main Methods:

  • Introduced a new statistical method for association testing in admixed populations.
  • The method allows effect size to depend on the ancestry of a given allele.
  • Does not require accurate inference of local ancestry.

Main Results:

  • Simulations show a substantial increase in statistical power to detect associations in some scenarios.
  • The method enables testing for differences in effect size between ancestral populations.
  • Demonstrated utility on data from the Greenlandic population.

Conclusions:

  • The developed method offers improved power for genetic association studies in admixed populations.
  • It provides a tool to investigate ancestry-specific effects and identify causal variants.
  • Applicable to diverse admixed populations, including the Greenlandic population.