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CARLo-7-A plausible biomarker for bladder cancer

Hina Amir1, Mohammad Azam Khan1, Saima Feroz1

  • 1Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.

International Journal of Experimental Pathology
|March 19, 2019
PubMed

Insights

CARLo-7 is a novel long non-coding RNA (lncRNA) specific to bladder cancer. Its expression correlates with tumor grade, suggesting CARLo-7 may serve as a prognostic marker for bladder cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer is characterized by uncontrolled cell growth and altered gene expression.
  • Non-coding RNAs, particularly long non-coding RNAs (lncRNAs), play crucial roles in regulating gene expression and have been implicated in cancer development.
  • Aberrant expression of lncRNAs is increasingly recognized for its functional significance in various cancers.

Purpose of the Study:

  • To identify and characterize novel cancer-specific long non-coding RNAs (lncRNAs).
  • To investigate the role of CARLo-7, a newly identified lncRNA, in bladder cancer.
  • To evaluate CARLo-7 as a potential prognostic marker for bladder cancer.

Main Methods:

  • Identification of bladder cancer-specific lncRNAs within the CARLos cluster.
  • Correlation analysis of CARLo-7 expression with bladder cancer grade.
  • Comparative analysis of CARLo-7 and MYC proto-oncogene expression in low- and high-grade tumors.

Main Results:

  • CARLo-7 was identified as the sole bladder cancer-specific lncRNA from the CARLos cluster.
  • CARLo-7 expression levels positively correlate with bladder cancer grade.
  • Unlike MYC, CARLo-7 shows a pronounced change in expression between low- and high-grade tumors, suggesting a specific role in bladder cancer progression.

Conclusions:

  • CARLo-7 is a bladder cancer-specific lncRNA with oncogenic potential.
  • CARLo-7 may function as a regulator of cell proliferation in bladder cancer.
  • CARLo-7 expression serves as a reliable prognostic marker for bladder cancer, outperforming MYC in this regard.
Keywords:
CARLo-7 (CASC11)MYCbladder cancerlong non-coding RNA

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