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The Clinical Trial Landscape for Melanoma Therapies

Sonia Wróbel1, Małgorzata Przybyło2, Ewa Stępień3

  • 1Department of Medical Physics, Marian Smoluchowski Institute of Physics, Jagiellonian University, 30-348 Krakow, Poland. soniawrobel1@gmail.com.

Journal of Clinical Medicine
|March 20, 2019
PubMed

Insights

Melanoma clinical trials are increasing, with most trials in the USA. Ipilimumab is the most studied drug, reflecting a trend towards precision medicine in cancer treatment.

Area of Science:

  • Oncology
  • Clinical Research
  • Dermatology

Background:

  • Melanoma remains a significant medical challenge despite extensive research.
  • Understanding trends in clinical trials is crucial for advancing treatment strategies.

Purpose of the Study:

  • To review publicly available melanoma clinical trials.
  • To identify trends in trial numbers, locations, interventions, and drug combinations.

Main Methods:

  • Surveyed the International Clinical Trials Registry Platform (ICTRP) for melanoma trials.
  • Conducted search on November 30, 2018, supplementing data from multiple repositories.
  • Analyzed 2563 registered clinical trials.

Main Results:

  • The USA hosted the majority of trials (58%, 1487 trials).
  • Ipilimumab was the most frequently studied intervention (251 trials).
  • A rise in immunomodulating monoclonal antibodies, targeted small molecules (BRAF, MEK, CDK4/6 inhibitors), and combination therapies was observed.

Conclusions:

  • Melanoma research shows a growing number of clinical trials.
  • There is a clear shift towards precision medicine approaches in melanoma treatment.
  • Combination therapies and targeted agents are increasingly investigated.
Keywords:
clinical trialsmelanomamelanoma drugmelanoma therapyreview

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