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PubMed
Summary

Marine organisms offer diverse natural products for drug discovery, particularly for antithrombotic applications. This review highlights marine sulfated polysaccharides and other novel scaffolds with potential to prevent blood clots.

Keywords:
anticoagulantantiplateletantithromboticglycosaminoglycansmarine-derivedpolysaccharidesulfated fucanssulfated galactans

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Area of Science:

  • Marine biology
  • Pharmacology
  • Natural products chemistry

Background:

  • Marine organisms are a rich, renewable source of diverse drug candidates.
  • Antithrombotic agents are crucial for managing thrombotic disorders.
  • Existing reviews primarily focus on marine sulfated polysaccharides for antithrombotic activity.

Purpose of the Study:

  • To provide an updated overview of marine-derived natural products with antithrombotic potential.
  • To highlight recent advancements in marine sulfated polysaccharides.
  • To identify and discuss other marine-derived molecular scaffolds with antithrombotic effects.

Main Methods:

  • Literature review of scientific databases (e.g., PubMed, Scopus).
  • Focus on studies published in the last few years.
  • Inclusion of research on both polysaccharides and other molecular structures.

Main Results:

  • A growing number of marine natural products exhibit antithrombotic activity.
  • Marine sulfated polysaccharides are well-documented for their anticoagulant and antithrombotic effects.
  • Other marine-derived molecular scaffolds are emerging as promising candidates for antithrombotic drug development.

Conclusions:

  • Marine natural products represent a valuable resource for novel antithrombotic agents.
  • Further investigation into diverse marine scaffolds beyond polysaccharides is warranted.
  • Continued research may lead to new therapeutic strategies for thrombotic diseases.