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How many of the digits in a mean of 12.3456789012 are worth reporting?
1School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. clymo@rsjc.net.
Objective:
A computer program tells me that a mean value is 12.3456789012, but how many of these digits are significant (the rest being random junk)? Should I report: 12.3?, 12.3456?, or even 10 (if only the first digit is significant)? There are several rules-of-thumb but, surprisingly (given that the problem is so common in science), none seem to be evidence-based.
Results:
Here I show how the significance of a digit in a particular decade of a mean depends on the standard error of the mean (SEM). I define an index, DM that can be plotted in graphs. From these a simple evidence-based rule for the number of significant digits ('sigdigs') is distilled: the last sigdig in the mean is in the same decade as the first or second non-zero digit in the SEM. As example, for mean 34.63 ± SEM 25.62, with n = 17, the reported value should be 35 ± 26. Digits beyond these contain little or no useful information, and should not be reported lest they damage your credibility.
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