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Family history of atopy in infants with cow's milk protein allergy: A French population-based study

N Kalach1, M Bellaïche2, I Elias-Billon3

  • 1Clinique pédiatrique Saint-Antoine, hôpital Saint-Vincent-de-Paul, groupement des hôpitaux de l'institut catholique de Lille (GHICL), boulevard de Belfort, 59020 Lille cedex, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|March 20, 2019
PubMed

Insights

Infants diagnosed with cow's milk protein allergy (CMPA) frequently have a family history of atopy, particularly in first-degree relatives. This highlights the importance of considering family history in diagnosing CMPA in infants.

Area of Science:

  • Pediatrics
  • Allergology
  • Genetics

Background:

  • Cow's milk protein allergy (CMPA) is a common condition in infants.
  • Family history of atopy is a known risk factor for allergic diseases.

Purpose of the Study:

  • To describe the prevalence of family history of atopy in infants with CMPA.
  • To analyze diagnostic approaches for CMPA in a real-world setting.

Main Methods:

  • A French multicenter, cross-sectional, observational study.
  • 1674 infants with suspected CMPA were enrolled by 466 private physicians.
  • Family history of atopy was defined by parental report of atopy in first- or second-degree relatives.

Main Results:

  • A family history of atopy was more common in infants with probable or documented CMPA (86% of cases).
  • Digestive (92%) and skin (61%) symptoms were most frequent.
  • Atopy in a parent was more frequent in infants with early-onset CMPA symptoms.

Conclusions:

  • The study confirms a high rate of family history of atopy in infants with CMPA.
  • Family history is a significant factor in the context of CMPA diagnosis.
Abstract

Keywords:
AtopyCow's milk protein allergyFamily history of atopyInfants

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