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Abnormal synchronization patterns in the electrical stimulation-contractile response coupling decrease with noise.

Alberto Peña-Romo1, Amelia Ríos1, Bruno A Escalante1

  • 1Centro de Investigación y de Estudios Advanzados del Instituto Politécnico Nacional (IPN), Vía del Conocimiento 201, Parque de Investigación e Innovación Tecnológica, 66600, Apodaca, NL, Mexico.

Bio Systems
|March 20, 2019
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Summary

This study shows that external electrical stimulation can synchronize heart contractions. Noise, present in biological systems, also influences this synchronization, impacting heart rate and contractile force.

Keywords:
Additive Gaussian noiseFrequency-lockingHigh-order modesNonlinear oscillatorSystems biology

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Area of Science:

  • Physiology
  • Biophysics
  • Nonlinear Dynamics

Background:

  • Synchronization theory explains how oscillators adjust frequency to external rhythms.
  • Noise is ubiquitous in biological systems, affecting physiological functions.
  • The heart, as an oscillator, is influenced by external stimuli and internal noise.

Purpose of the Study:

  • To experimentally investigate if noise can induce higher-order synchronization in the heart's mechanical response.
  • To analyze the effect of noisy periodic electrical stimulation on cardiac function.

Main Methods:

  • Utilized a Langendorff heart preparation for ex vivo experiments.
  • Measured contractile force intensity and heart rate as key mechanical responses.
  • Applied periodic electrical stimulation with and without induced noise.

Main Results:

  • Observed frequency locking between electrical stimulation and the heart's mechanical response.
  • Demonstrated that synchronization occurs both with and without the presence of noise.
  • Noise did not prevent, and potentially influenced, the synchronization phenomenon.

Conclusions:

  • The heart's mechanical response synchronizes with external electrical stimulation.
  • Noise plays a role in the synchronization dynamics of biological oscillators like the heart.
  • Further research is needed to understand noise's impact on effector organ responses.