The citrus flavonoids hesperidin and naringin alleviate alcohol-induced behavioural alterations and developmental
Xingyu Liu1, Meng Li1, Xizeng Feng1
1State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China.
Abstract:
This study aimed to investigate the protective effects of two citrus flavonoids, hesperidin and naringin, on alcohol-induced thigmotaxis behavioural and developmental defects in zebrafish. The results of behavioural assays indicated that acute exposure to 1% alcohol could induce thigmotaxis behaviour in zebrafish larvae at 3 and 5 days post-fertilization (dpf), whereas hesperidin and naringin could inhibit the thigmotaxis behaviour in zebrafish larvae. Moreover, developmental administration of hesperidin and naringin reduced the levels of morphological defects and apoptosis induced by developmental alcohol exposure. In conclusion, this study suggests that the citrus flavonoids hesperidin and naringin could reduce the effects of alcohol damage on embryonic development and neurobehaviour in zebrafish larvae, which would provide useful knowledge for assessing the underlying mechanism of citrus flavonoids and their protective effects.
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