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Message in a vesicle - trans-kingdom intercommunication at the vector-host interface

Adela S Oliva Chávez1, Anya J O'Neal1, Laura Santambrogio2

  • 1Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Journal of Cell Science
|March 20, 2019
PubMed

Insights

Vector-borne diseases are a major global health threat. Extracellular vesicles play a key role in pathogen transmission, host colonization, and disease development, impacting microbial pathogenesis and immunity.

Area of Science:

  • Vector-borne disease research
  • Microbial pathogenesis
  • Immunology

Background:

  • Vector-borne diseases cause significant global mortality and morbidity.
  • Understanding arthropod vector, microbe, and host interactions is critical.
  • The vector-host interface is crucial for pathogen acquisition and transmission.

Purpose of the Study:

  • To review the biogenesis and cargo of extracellular vesicles (EVs).
  • To explore the role of nanovesicles in pathogen spread and host colonization.
  • To focus on the function of EVs in microbial pathogenesis and host immunity during vector-borne pathogen transmission.

Main Methods:

  • Literature review of exosome and microvesicle biogenesis and cargo.
  • Analysis of the role of nanovesicles in pathogen transmission dynamics.
  • Focus on the impact of EVs on host immunity and microbial pathogenesis.

Main Results:

  • Extracellular vesicles mediate cell-to-cell communication and molecular interactions.
  • Nanovesicles are involved in pathogen spread, host colonization, and disease.
  • EVs play a significant role in microbial pathogenesis and host immune responses during vector-borne disease transmission.

Conclusions:

  • Extracellular vesicles are key mediators in the complex interactions within vector-borne diseases.
  • Understanding EV function is essential for developing strategies against vector-borne pathogens.
  • EVs influence both pathogen virulence and host immune evasion during transmission.
Keywords:
Arthropod-borne diseaseCell communicationExtracellular vesicleImmunomodulationMicrobial transmission

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