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Related Experiment Video

Updated: Jan 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Experimental and quantitative imaging techniques in interstitial lung disease.

Nicholas D Weatherley¹, James A Eaden¹, Neil J Stewart¹

¹Academic Unit of Academic Radiology, University of Sheffield, Sheffield, UK.

|March 20, 2019

Summary

Quantitative imaging offers new biomarkers for interstitial lung diseases (ILDs), improving monitoring and treatment. Novel techniques like texture analysis and PET scans provide objective disease assessment, aiding personalized therapy and drug development.

Keywords:

drug induced lung disease idiopathic pulmonary fibrosis imaging/ct mri etc interstitial fibrosis

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Published on: April 1, 2015

Area of Science:

Radiology
Pulmonology
Medical Imaging

Background:

Interstitial lung diseases (ILDs) present diverse imaging features, complicating monitoring and treatment due to a lack of robust biomarkers.
Current CT analysis for ILDs is largely qualitative and subjective, limiting objective assessment of disease progression.

Purpose of the Study:

To review novel and quantitative imaging techniques for ILD assessment.
To explore how these advanced methods can improve understanding, monitoring, and treatment of ILDs.

Main Methods:

Systematic literature search of Ovid, PubMed, and TRIP for novel and quantitative imaging studies in ILD.
Appraisal of evidence on texture-based analysis, pulmonary vessel volume analysis, hyperpolarized gas MRI, and PET imaging in ILD.

Main Results:

Texture-based analysis shows promise in quantifying ILD features objectively, distinguishing complex patterns like reticulation and honeycombing.
Pulmonary vessel volume analysis on CT has prognostic value, potentially indicating vascular changes in ILD.
Advanced techniques like hyperpolarized gas MRI and PET offer combined structural and functional insights, with PET showing unexpected metabolic activity in fibrosed lung tissue.

Conclusions:

Multimodal quantitative imaging can identify sensitive, clinically applicable biomarkers for ILD diagnosis, prognosis, and treatment response.
Objective imaging metrics may surpass traditional pulmonary function tests in detecting subtle disease changes and guiding personalized therapies.
Quantitative imaging holds potential for monitoring antifibrotic therapy efficacy and early detection of drug-induced lung injury.