Related Experiment Video
Updated: Jan 27, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
Breastfeeding and cardiometabolic markers at age 12: a population-based birth cohort study
L P M Pluymen1, A H Wijga2, U Gehring3
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. lindapluymen@live.nl.
Insights
Breastfeeding is linked to better heart health in children. Breastfed children at age 12 had lower blood pressure, smaller waist circumference, and reduced risk of being overweight.
Area of Science:
- Pediatric Health
- Cardiovascular Health
- Metabolic Health
Background:
- Emerging evidence suggests breastfeeding protects against overweight and diabetes.
- However, its impact on childhood cardiometabolic profiles remains less clear.
Purpose of the Study:
- To investigate if breastfed children have improved cardiometabolic markers at age 12 compared to formula-fed children.
- To determine if the duration of breastfeeding influences these associations.
Main Methods:
- 1509 children from the PIAMA birth cohort study had cardiometabolic markers measured at age 12.
- Breastfeeding duration was recorded via parental questionnaires.
- Multivariable regression analyses assessed associations between breastfeeding and blood pressure, cholesterol, HbA1c, BMI, waist circumference, and overweight status.
Main Results:
- 85.3% of children were breastfed. Breastfed children showed lower systolic and diastolic blood pressure Z-scores, smaller waist circumference, and reduced odds of being overweight.
- These associations were consistent regardless of breastfeeding duration.
- No significant differences were found in total-to-HDL cholesterol, HbA1c, or BMI.
Conclusions:
- Breastfeeding is associated with favorable cardiometabolic markers in 12-year-old children, including lower blood pressure, smaller waist circumference, and reduced overweight risk.
- These benefits appear independent of breastfeeding duration.
- Breastfeeding did not show associations with cholesterol, HbA1c, or BMI in this cohort.
Background:
There is growing evidence for a protective effect of breastfeeding against overweight and diabetes. It is less clear though, whether breastfed infants also have a more favorable cardiometabolic profile in childhood.
Objective:
We investigated whether children who were breastfed in infancy had more favorable cardiometabolic markers at 12 years of age than children who were never breastfed and received formula milk instead, and whether associations depended on the duration of breastfeeding.
Methods:
In 1509 participants of the population-based PIAMA birth cohort study, cardiometabolic markers were measured at 12 years of age. Duration of breastfeeding in weeks was assessed through parental questionnaires at 3 months and 1 year of age. Multivariable linear regression analysis was used to investigate associations of breastfeeding (any vs. never breastfeeding and duration of breastfeeding in categories <3 months, 3 to <6 months, and ≥6 months breastfeeding vs. never breastfeeding) with systolic and diastolic blood pressure (SBP and DBP, in Z-scores adjusted for age, sex, and height), total-to-high-density lipoprotein cholesterol (TC/HDLC), glycated hemoglobin (HbA1c, in mmol/mol), body mass index (BMI, in Z-scores adjusted for age and sex) and waist circumference (WC, in cm). Multivariable logistic regression was used to investigate the association of breastfeeding with odds of being overweight.
Results:
1288 of 1509 children (85.3%) received any breastmilk in infancy. Breastfed children had a lower SBP Z-score (-0.21 SD (≈ -2.29 mmHg), 95% CI -0.37, -0.06), a lower DBP Z-score (-0.10 SD (≈ -1.19 mmHg), 95% CI -0.20, -0.00), a smaller WC (-1.12 cm, 95% CI -2.20; -0.04), and lower odds of being overweight (OR 0.61, 95% CI 0.38, 0.97) than never breastfed children. These associations were not different between children with shorter and longer duration of breastfeeding. No statistically significant differences in TC/HDLC, HbA1c, and BMI were observed between breastfed and never breastfed children.
Conclusions:
We observed that breastfeeding was associated with a lower blood pressure, a smaller waist circumference and a lower risk of overweight in 12-year old children. These associations were independent of the duration of breastfeeding. No associations were observed between breastfeeding and other cardiometabolic markers.
More Related Videos
05:04A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
05:53Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Related Concept Videos
Birth Control Methods
What is Population Genetics?
Conservation of Small Populations
Population Growth
What are Populations and Communities?
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...