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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

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A nuclear phosphoinositide kinase complex regulates p53.

Suyong Choi1, Mo Chen1, Vincent L Cryns2

  • 1University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.

Nature Cell Biology
|March 20, 2019
PubMed
Summary

The tumor suppressor p53 stability is regulated by PIPKI-α and PtdIns(4,5)P2. This phosphoinositide pathway stabilizes nuclear p53, offering a new cancer therapy target.

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