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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With

Liuping Xiao1, Bo Ge2, Xu Chen3

  • 1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.

Frontiers in Aging Neuroscience
|March 20, 2019
PubMed

Insights

A higher dipeptidyl peptidase-4 (DPP4) activity to brain-derived neurotrophic factor (BDNF) ratio (DBR) is linked to increased mild cognitive impairment (MCI) risk in older adults. This ratio may serve as a novel biomarker for MCI.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Gerontology

Background:

  • Decreased brain-derived neurotrophic factor (BDNF) and increased dipeptidyl peptidase-4 (DPP4) activity are implicated in mild cognitive impairment (MCI).
  • Oxidative stress markers, such as nitrotyrosine and 8-iso-PGF2a, may play a role in the pathogenesis of MCI.

Purpose of the Study:

  • To evaluate the association between the plasma DPP4 activity to BDNF ratio (DBR) and MCI in elderly individuals with normal glucose tolerance.
  • To investigate the mediating roles of oxidative stress and inflammation in the relationship between DBR and MCI.

Main Methods:

  • Cross-sectional study of 1,066 elderly Chinese participants with normal glucose tolerance.
  • Measurement of plasma C-reactive protein, interleukin-6, nitrotyrosine, 8-iso-PGF2a, DPP4 activity, and BDNF.
  • Calculation of the DBR and assessment of MCI using the Montreal Cognitive Assessment, confirmed by neurologists.

Main Results:

  • A significant inverse correlation was observed between DPP4 activity and BDNF (r = -0.456, P < 0.001), partly mediated by nitrotyrosine and 8-iso-PGF2a.
  • Increasing quartiles of DBR were associated with increased oxidative stress and inflammation markers and decreased Montreal Cognitive Assessment scores.
  • Higher MCI risk was found in individuals with the lowest BDNF and highest DBR and DPP4 activity quartiles.

Conclusions:

  • A negative correlation exists between DPP4 activity and BDNF, mediated by oxidative stress, not inflammation.
  • The DBR is positively associated with MCI and may serve as a novel risk biomarker in elderly individuals with normal glucose tolerance.
Keywords:
DPP4 activity to BDNF ratioinflammationmild cognitive impairmentnormal glucose toleranceoxidative stress

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