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Cognitive function, depression, and quality of life in patients with ruptured cerebral aneurysms

Samira Zabyhian1, Seyed Javad Mousavi-Bayegi1, Humain Baharvahdat1

  • 1Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Iranian Journal of Neurology
|March 20, 2019
PubMed

Insights

Neuropsychiatric dysfunction is common after aneurysmal subarachnoid hemorrhage (aSAH), impacting cognitive function, depression, and quality of life even in patients with good functional outcomes. Early evaluation and management are crucial.

Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Aneurysmal subarachnoid hemorrhage (aSAH) frequently leads to neuropsychiatric complications.
  • These include deficits in cognitive function, mood disorders like depression, and reduced quality of life (QOL).
  • Understanding these sequelae is vital for patient recovery and management.

Purpose of the Study:

  • To prospectively evaluate cognitive function, depression, and QOL in aSAH patients with good functional outcomes.
  • To identify risk factors associated with cognitive dysfunction post-aSAH.
  • To inform clinical practice regarding the long-term care of aSAH survivors.

Main Methods:

  • Prospective enrollment of aSAH patients with anterior circulation aneurysms and modified Rankin Scale (mRS) > 2.
  • Assessment of cognitive function using Mini-Mental State Examination (MMSE).
  • Evaluation of depression with Hospital Anxiety and Depression Scale (HADS) and QOL using the SF-36 survey at 6 months post-intervention (microsurgery or endovascular treatment).

Main Results:

  • Fifty-three patients were included, with a mean age of 50.9 years.
  • Significant impact on QOL was observed in most patients.
  • High prevalence of depression (55%) and cognitive impairment (57%) was noted, with older age being a risk factor for cognitive decline (P < 0.001).

Conclusions:

  • Neuropsychological deficits are prevalent in aSAH patients, even those achieving good functional recovery (mRS > 2).
  • Routine neuropsychological assessment is recommended for early detection and management of these common complications.
  • Timely intervention can improve long-term outcomes for aSAH survivors.

Keywords:
Cerebral AneurysmCognitive ImpairmentDepressionNeuropsychological TestQuality of LifeSubarachnoid Hemorrhage

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