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Updated: Jan 27, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.7K

[Influence of modern diagnostic methods on the treatment of nonmetastatic castration-resistant prostate cancer]

A Kretschmer1, D Tilki2,3

  • 1Urologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians Universität München, München, Deutschland.

Der Urologe. Ausg. A
|March 20, 2019
PubMed

Insights

Until 2018, nonmetastatic castration-resistant prostate cancer (nmCRPC) lacked standard care. Novel treatments and advanced imaging like 68Ga-PSMA-PET/CT are changing nmCRPC diagnosis and management.

Area of Science:

  • Oncology
  • Radiology

Background:

  • Nonmetastatic castration-resistant prostate cancer (nmCRPC) previously lacked a standard of care.
  • Patient management was individualized and lacked comparative analysis.

Purpose of the Study:

  • To review nmCRPC and novel therapeutic options.
  • To discuss the impact of advanced imaging on nmCRPC diagnosis.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of SPARTAN and PROSPER trial data.
  • Discussion of 68Ga-PSMA-PET/CT imaging.

Main Results:

  • Novel treatments have emerged for nmCRPC.
  • 68Ga-PSMA-PET/CT may redefine nmCRPC diagnosis.
  • The incidence of true nmCRPC may decrease with new imaging.

Conclusions:

  • New therapeutic options improve nmCRPC management.
  • Advanced imaging like 68Ga-PSMA-PET/CT is crucial for accurate nmCRPC diagnosis.
  • Future incidence of nmCRPC may be impacted by diagnostic advancements.
Keywords:
ApalutamideBicalutamideEnzalutamideLymph nodesMetastasis

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