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Updated: Jan 27, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with
Sakiko Shimizu Handa1, Shingo Baba2, Kenichiro Yamashita3
1Sleep Apnea Center, Kyushu University Hospital, Fukuoka, Japan.
Objective:
Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer's disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.
Method:
We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea-hypopnea index: 43.8 ± 26.3/h).
Results:
The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe.
Conclusions:
The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.
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