Effect of dietary fat on aflatoxin B1-induced chromosomal aberrations in mice

The effect on the frequency of aflatoxin B1 (AFB1)-induced chromosomal aberrations in bone marrow cells of mice fed diets containing increasing levels of sesame oil was investigated. Mice receiving either 9% or 12% sesame oil in their diet for 8 weeks presented a statistically increased AFB1-induced aberration rate as compared to those given a diet containing 3% sesame oil. These data suggest that the metabolism of a mutagen can be influenced by the dietary lipid intake of the test animal.