Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Du confirmation.

P J Schmidt, R E Klein, W C Sherwood

|July 1, 1986

Summary

This summary is machine-generated.

Repeat antiglobulin testing for Du phenotype in Rh-negative donor blood is unnecessary. Confirmatory testing by hospital transfusion services rarely rejects units, suggesting current protocols can be simplified.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hepcidin is not essential for mediating testosterone's effects on erythropoiesis.

Andrology·2019

Same author

Confirming the need for virus disinfection in municipal subsurface drinking water supplies.

Water research·2019

Same author

The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback.

Translational psychiatry·2017

Same author

Brain-derived neurotrophic factor Val<sup>66</sup>Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study.

Molecular psychiatry·2017

Same author

The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder.

Molecular psychiatry·2017

Same author

The impact of education, country, race and ethnicity on the self-report of postpartum depression using the Edinburgh Postnatal Depression Scale.

Psychological medicine·2016

Area of Science:

Transfusion Medicine
Immunology
Blood Banking

Background:

Rh-negative blood is crucial for transfusion safety.
The Du phenotype requires specific identification to prevent alloimmunization.
Current protocols mandate repeat antiglobulin testing for Du in Rh-negative donors.

Purpose of the Study:

To evaluate the necessity of repeat antiglobulin testing for Du phenotype detection in Rh-negative donor blood.
To assess the impact of current confirmatory testing practices on blood supply.

Main Methods:

Retrospective analysis of blood bank records.
Review of confirmatory antiglobulin test results for Du phenotype.
Calculation of rejection rates for Rh-negative donor units.

Related Experiment Videos

Main Results:

Only 47 out of 2.6 million tested donor units were rejected.
The confirmatory antiglobulin test for Du demonstrated a very low positive rate.
The current confirmatory testing yields minimal additional clinically significant findings.

Conclusions:

The routine confirmatory antiglobulin test for Du phenotype in Rh-negative donor blood is not cost-effective.
Hospital transfusion services can likely omit this confirmatory step without compromising patient safety.
Streamlining transfusion protocols can improve efficiency in blood banking.